Morrie (Matthew Perry) is the keeper of all things family related, including his siblings. In this comedic foray into sibling relationships, Morrie's little brother Jay (Ben Foster) is beyond peculiar, homeless and humorously, but clinically, depressed. His beautiful sister Ida (Ginnifer Goodwin) is a promiscuous insomniac and sometime photographer that is starved for attention. Morrie's wife Betty (Lauren Graham) has waited patiently for 7 years for their hard work to pay off so they can start a family. Morrie's life is unraveling. As his family's antics infuriate his boss and neighbor, his dreams of success are quickly destroyed.