Returning home to the small Louisiana parish where he had praticed psychiatry, Dr. Tom More quickly notices something strange occuring with the townfolk, a loss of inhibitions. Behind this mystery is a dangerous plot drug the local water supply, and a discovery that takes More into the underside of the American search for happiness.
""There is ample evidence of Percy's brilliance in The Thanatos Syndrome - the droll Dixie anthropology, the pitch-perfect dialogue, the sheer intelligence everywhere on the page.... It is splendidly, uproariously catholic, as well."" --Douglas Bauer, Atlantic Monthly